Open AccessУЛЬТРАМІКРОСКОПІЧНІ ПРОЯВИ У СТРУКТУРІ ПІДНИЖНЬОЩЕЛЕПНОЇ СЛИННОЇ ЗАЛОЗИ НАПРИКІНЦІ 4-ГО ТИЖНЯ ЕКСПЕРИМЕНТАЛЬНОГО ОПІОЇДНОГО ВПЛИВУ
Author(s) -
Mykhalevych Marta
Publication year - 2020
Publication title -
science review
Language(s) - English
Resource type - Journals
eISSN - 2544-9443
pISSN - 2544-9346
DOI - 10.31435/rsglobal_sr/30042020/7049
Subject(s) - endoplasmic reticulum , organelle , ultrastructure , nucleus , salivary gland , mitochondrion , microbiology and biotechnology , secretion , submandibular gland , cell , chemistry , secretory pathway , biology , endocrinology , anatomy , golgi apparatus , biochemistry
This publication demonstrates the ultrastructural changes of the submandibular salivary gland under the opioid effect at the 4th week of the experimental research. After 28 days of experimental opioid effect, we found that in exocrinocytes of the end secretory departments of acinar cells revealed the destruction of organelles, especially granular and smooth endoplasmic reticulum, mitochondria, as well as reducing the content of secretory granules in the apical area of glandulocytes. In some exocrinocytes, as a result of the increase in destructive changes, a decrease in the volume of the nucleus was noted, which moved to the peripheral parts of the cell. Necrotic changes developed in individual exocrinocytes of the final secretory protein divisions. In such cells, the nucleus was reduced in volume, filled with heterochromatin.