Open AccessStudy of the dynamics of anticonvulsant and anxiolytic action after oral administration of tin (II) chloride
Author(s) -
О. G. Prokopchuk,
O. I. Aleksandrova,
Iryna Kravchenko
Publication year - 2019
Publication title -
vìsnik vìnnicʹkogo nacìonalʹnogo medičnogo unìversitetu
Language(s) - English
Resource type - Journals
eISSN - 2522-9354
pISSN - 1817-7883
DOI - 10.31393/reports-vnmedical-2019-23(2)-03
Subject(s) - anxiolytic , anticonvulsant , tonic (physiology) , sedative , pharmacology , open field , chemistry , tin , elevated plus maze , chloride , anesthesia , medicine , anxiety , epilepsy , psychiatry , organic chemistry
This article is devoted to the study of anticonvulsant and anxiolytic activity of tin (II) chloride by oral administration. The anxiolytic effect was established in models of the Open Field and Black-and-White Camera tests; the anticonvulsant activity of SnCl (II) was evaluated in model of acute generalized seizures with the determination of pentylenetetrazole (PTZ) minimum effective doses inducing clonic-tonic convulsions and tonic extension in test animals. Statistical indicators were calculated using the Microsoft Excel software package using the arithmetic mean value (M) and the mean deviation mean value (m). The obtained data show that tin (II) chloride is a promising compound for the prevention of anxiety states, as well as disorders containing the convulsive component. Three hours after the start of the experiment, the minimum doses of pentylenetetrazole for inducing clonic-tonic convulsions and tonic extension, exceeded the control group data by an average of 75%. A decrease in motor activity by half compared with the control in the open field test during the 5 hours of the experiment indicates the sedative effect of tin (II) chloride. Tin (II) chloride is a promising compound for the relief of convulsive states and correction of depressive disorders. Thus, it is of interest to further study the spectrum of its pharmacological activity in order the use it in medicine.