Efficiency of treatment of patients with non-alcoholic steatohepatitis combined with diabetes mellitus type 2 using the s-adenosylmethionin

Non-alcoholic fatty liver disease is an important cause of chronic liver damage in many countries and is growing rapidly in both adults and children due to obesity and diabetes type 2. Aim — investigate the effectiveness of complex treatment of patients for the course of NASH using S-adenosylmethionin on the background of basic therapy. The study included 25 patients with non-alcoholic steatohepatitis against type 2 diabetes, age on average (58.69±1.25) years. The control group comprised 15 healthy individuals. In order to identify the diagnosis, data from clinical and laboratory, biochemical and instrumental studies were fully integrated into account. Statistical processing of the results was carried out using Statistica 6.1. In the group of patients with NASH before treatment, the stage I of hepatosis was observed in 15% of cases, the second — in 50%, the third in 35%. Lipid blood spectrum revealed high levels of low and very low density lipoprotein and low levels of high density lipoprotein. High levels of triglycerides among men and high thyroid test among women were determined. The results of the complex (with the inclusion of S-adenosylmethionine) treatment for patients with NASH showed a significant improvement in the subjective state of patients: reduced complaints of discomfort in the right hypochondrium, general weakness, nausea and dizziness. In the ultrasound study in the group of NASH, the redistribution of the number of patients in the side with the reduction of heavier stages of hepatosis was observed: the number of patients with stage I hepatosis was determined in 52.9% of cases (an increase of 3.5 times), stage II — in 24.9% (reduction in 2 times), the third stage — in 22,2% (reduction by 1,5 times). Among all patients, the cytolysis, mesenchymal-inflammatory syndrome, cytology, hemograms improved, and lipid and metabolic parameters were stabilized, confirming the positive membranotropic effect of S-adenosylmethionin on the membrane structures of hepatocytes and indicating anti-inflammatory, hepatoprotective and regenerative effects of the drug in the treatment of patients with steatohepatitis combined diabetes mellitus type 2.