Open AccessEXPERIMENTAL STUDY OF ULCEROGENIC ACTION OF PROPOXAZEPAM
Author(s) -
Н. І. Волощук,
И. В. Таран,
А. С. Редер,
N. Ya. Golovenko
Publication year - 2018
Publication title -
vìsnik vìnnicʹkogo nacìonalʹnogo medičnogo unìversitetu
Language(s) - English
Resource type - Journals
eISSN - 2522-9354
pISSN - 1817-7883
DOI - 10.31393/reports-vnmedical-2018-22(1)-01
Subject(s) - distilled water , stomach , gastrointestinal tract , oral administration , chemistry , pharmacology , medicine , biochemistry , chromatography
In experiments on 94 white male rats in the Wistar line, were studied changes in the gastric mucous under the acute, subchronic and chronic conditions after introduction of a new original derivative of benzodiazepine – proxazepam. The study of gastrotoxicity of propoxazepam was carried out under conditions of its intragastric administration with Tween-80 solvents and distilled water. It has been established that propoxazepam does not exhibit a damaging effect on the stomach in the conditions of acute (3 hours after, 50, 250, 500 and 1000 mg/kg perorally), as well as subacute (within 4 days, 50 mg/kg perorally) and chronic (within 28 days, 0,5 mg/kg perorally) administration, and also does not change the dietary behavior and general activity of animals, which is confirmation of harmlessness of this compound, in particular, on the gastrointestinal tract.