Open AccessDopamine transporter knockout rats as the new preclinical model of hyper- and hypo-dopaminergic disorders
Author(s) -
I. Sukhanov,
Damiana Leo,
M. Tur,
Irina Belozertseva,
А. Савченко,
Raul R. Gainetdinov
Publication year - 2019
Publication title -
obozrenie psihiatrii i medicinskoj psihologii im. v.m. behtereva/obozrenie psihiatrii i medicinskoj psihologii imeni v.m. behtereva
Language(s) - English
Resource type - Journals
eISSN - 2713-055X
pISSN - 2313-7053
DOI - 10.31363/2313-7053-2019-4-1-84-85
Subject(s) - dopamine transporter , dopaminergic , dopamine , methylphenidate , amphetamine , dopamine plasma membrane transport proteins , levodopa , neuroscience , knockout mouse , genetically modified mouse , dextroamphetamine , medicine , psychology , disease , pharmacology , parkinson's disease , endocrinology , attention deficit hyperactivity disorder , chemistry , transgene , psychiatry , biochemistry , receptor , gene
Rat line lacking the dopamine transporter (DAT-KO rats) was recently developed. Lack of DAT in these mutants manifests behaviorally as spontaneous hyperactivity and cognitive deficits. It has been shown that d-amphetamine and methylphenidate paradoxically calm down these animals. Also, the inhibition of dopamine synthesis in DAT-KO rats represents a straightforward approach for developing the model of severe dopamine deficiency exhibiting characteristic akinetic phenotype which can be reversed by treatment with L-DOPA that used in Parkinson’s disease. These results support the usefulness of DAT-KO rats as models of the disorders associated with dopaminergic dysfunction.