Open AccessPolymorphic variants of xenobiotic metabolism genes and body mass index in schizophrenia patients receiving antipsychotic therapy
Author(s) -
Ivan V Pozhidaev,
Anastasiia S. Boiko,
E. Kornetova
Publication year - 2019
Publication title -
obozrenie psihiatrii i medicinskoj psihologii im. v.m. behtereva/obozrenie psihiatrii i medicinskoj psihologii imeni v.m. behtereva
Language(s) - English
Resource type - Journals
eISSN - 2713-055X
pISSN - 2313-7053
DOI - 10.31363/2313-7053-2019-4-1-115-117
Subject(s) - antipsychotic , schizophrenia (object oriented programming) , cyp2c19 , body mass index , pharmacogenetics , medicine , pharmacotherapy , cyp2d6 , allele , cyp1a2 , genotype , genetics , psychiatry , cytochrome p450 , gene , biology , metabolism
The use of atypical antipsychotic drugs has made metabolic disorders one of the most common side effect of pharmacotherapy for schizophrenic patients. The aim of this study was to assess the contribution of polymorphic variants of genes of the P450 cytochrome system to changes in body mass index in patients with schizophrenia. As a result of the study, we did not identify significant associations of genotypes and alleles of the studied polymorphic variants of the CYP2D6, CYP1A2, CYP2C19 genes with weight gain in patients with schizophrenia of Russian nationality of the Siberian region receiving antipsychotic therapy and can revealed neither protective nor predisposing effects. Metabolic syndrome and, increase in body weight especially, are complex side effect, and further studies is needed to increase successful exploration and identification of the genetic component and assess contribution.