Open AccessCholine Alphoscerat (Gliatilin) in the pathogenetic therapy of Alzheimer’s disease
Author(s) -
D. V. Zaharov,
V. A. Mihailov,
Y. V. Kotsiubinskaya
Publication year - 2019
Publication title -
obozrenie psihiatrii i medicinskoj psihologii im. v.m. behtereva/obozrenie psihiatrii i medicinskoj psihologii imeni v.m. behtereva
Language(s) - English
Resource type - Journals
eISSN - 2713-055X
pISSN - 2313-7053
DOI - 10.31363/2313-7053-2018-4-93-99
Subject(s) - choline , acetylcholine , cholinergic , alzheimer's disease , neuroscience , central nervous system , cholinergic neuron , medicine , phosphatidylcholine , phospholipid , endocrinology , chemistry , biology , disease , biochemistry , membrane
Alzheimer’s disease (Alzheimer’s type dementia) (BA) is a primary progressive neurodegenerative disease of the brain with characteristic clinical and pathological features, individual characteristics of the course and severity of symptoms, as well as multiple converging etiopathogenetic mechanisms. Te most successfully developed at the present time are compensatory (replacement) therapy aimed at overcoming the neurotransmitter defciency in various neuronal systems, which are more or less aected by the development of Alzheimer’s disease. Choline alfoscerat (Gliatilin) is a cholinomimetic of central action with a predominant eect on the central nervous system. In the process of metabolism, the molecule of Gliatilin (choline alphoscerate) undergoes cleavage into choline (40.5%) and glycerophosphate. Te resulting choline stimulates the synthesis of acetylcholine, which improves the transmission of nerve impulses in cholinergic neurons, and glycerophosphate stimulates the appearance of phosphatidylcholine, which restores the phospholipid composition of neuronal membranes, improving their plasticity. Glitatylin (choline alfoscerate) has a stimulating eect on cognitive functions and improves memory and attention, leads to the correction of psycho-emotional disorders. Glitatilin (choline alphosceratus) positively increases in cerebral blood ow, accelerates metabolism and activates structure brain reticular formation. Te eect on glia is expressed in suppressing the activation of inammation, reducing intracellular edema and reducing microvascular permeability. Choline alfostserat (Gliatilin) can be recommended for use in patients with asthma as monotherapy, and about complex treatment.