Open AccessThe role of acetylcholine neurotransmission in the pharmacotherapy of cognitive dysfunction
Author(s) -
D. V. Zaharov,
V. A. Mihailov
Publication year - 2018
Publication title -
obozrenie psihiatrii i medicinskoj psihologii im. v.m. behtereva/obozrenie psihiatrii i medicinskoj psihologii imeni v.m. behtereva
Language(s) - English
Resource type - Journals
eISSN - 2713-055X
pISSN - 2313-7053
DOI - 10.31363/2313-7053-2018-3-90-96
Subject(s) - acetylcholine , choline , neuroscience , cholinergic , dementia , medicine , cognition , central nervous system , pharmacotherapy , neurotransmission , pharmacology , psychology , disease , receptor
Microangiopathy and deficit in cholinergic system innervating cerebral cortex and controlling the plasticity of neuronal structuresplay an important role in the formation of cognitive disorders. The main approaches to the therapy of dementia and organic lesions followed by cognitive disorder are based on the hypothesis of replenishment of acetylcholine. Choline alfoscerate takes a special place among the precursors of choline due to its proven effectiveness in the treatment of ischemic and neurodegenerative lesions of the central nervous system. The article presents the materials of experimental and clinical studies of the drug choline alfostserat (Gliatilin).