Ameliorative Effects of the Aqueous Extract of Allium porrum (Wild Leek) against Cisplatin-Induced Nephrotoxicity in Rabbits | Zendy

HS Mohammed | Zendy; MHS Ahmida | Zendy; MF Madi | Zendy; A A Abdel-Gayoum | Zendy

Open Access

Ameliorative Effects of the Aqueous Extract of Allium porrum (Wild Leek) against Cisplatin-Induced Nephrotoxicity in Rabbits

Author(s) -

HS Mohammed,

MHS Ahmida,

MF Madi,

A A Abdel-Gayoum

Publication year - 2021

Publication title -

iraqi journal of pharmaceutical sciences ( p-issn 1683 - 3597 e-issn 2521 - 3512)

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.122

H-Index - 1

eISSN - 2521-3512

pISSN - 1683-3597

DOI - 10.31351/vol30iss2pp177-184

Subject(s) - nephrotoxicity , distilled water , cisplatin , aqueous extract , intraperitoneal injection , medicine , pharmacology , chemistry , toxicity , traditional medicine , chemotherapy , chromatography

The aim of the present study was to investigate the nephroprotective, hypolipidemic and hypoglycemic effects of Allium porrum (leek) in rabbits with cisplatin nephrotoxicity. Forty adult male New Zealand rabbits were divided randomly into four groups (ten rabbits in each group) as follows: Group I: (negative control) (C) received oral daily dose of distilled water for 15 successive days. Groups II: (Leek) (L) received oral daily dose of aqueous leek extract (500mg/kg/day) for 15 successive days. Group III: (positive control) [cisplatin (CP)] received oral daily dose of distilled water for 15 successive days, and subsequently administered single dose of Cisplatin (3.5mg/kg/day) by intraperitoneal injection from day 10 for five days. Groups IV: (Leek and Cisplatin

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