Open AccessSynthesis, Characterization and Antibacterial Evaluation of Some Coumarin Derivatives
Author(s) -
Tariq T. Abduljabbar,
Mohammed K. Hadi
Publication year - 2021
Publication title -
al-maǧallaẗ al-’irāqiyyaẗ li-l-’ulūm al-ṣaydalāniyyaẗ/iraqi journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.122
H-Index - 1
eISSN - 2521-3512
pISSN - 1683-3597
DOI - 10.31351/vol30iss1pp249-257
Subject(s) - coumarin , pseudomonas aeruginosa , chemistry , antibacterial activity , bacteria , staphylococcus aureus , streptococcus pneumoniae , amide , antibiotics , microbiology and biotechnology , organic chemistry , biochemistry , biology , genetics
Coumarin derivatives have shown different biological activities, such as antifungal, antibacterial antiinflammatory, and antioxidant activities, besides antibiotic resistance modulating effects, and anti-HIV, hepatoprotective, and antitumor effect. So, new coumarin derivatives (hydrazones and an amide) were synthesized through multisteps reactions. All the synthesized target compounds were characterized by FT-IR spectroscopy, 1HNMR analysis. The compounds then evaluated for their anti-bacterial activity by means of well-diffusion method against two gram-positive bacteria (Staphylococcus aureus, Streptococcus pneumoniae) and two gram-negative bacteria (E.coli and Pseudomonas aeruginosa). The highest activity was demonstrate by compound k2 which found to be highly active against pseudomonas aeruginosa.