The Pathological Mechanisms of Obesity-Related Glomerulopathy: A review article | Zendy

Ali A. Kasim | Zendy; Ahmed H. Ataimish | Zendy

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The Pathological Mechanisms of Obesity-Related Glomerulopathy: A review article

Author(s) -

Ali A. Kasim,

Ahmed H. Ataimish

Publication year - 2021

Publication title -

iraqi journal of pharmaceutical sciences ( p-issn 1683 - 3597 e-issn 2521 - 3512)

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.122

H-Index - 1

eISSN - 2521-3512

pISSN - 1683-3597

DOI - 10.31351/vol30iss1pp22-28

Subject(s) - medicine , glomerulopathy , pathological , focal segmental glomerulosclerosis , proteinuria , microalbuminuria , glomerulosclerosis , disease , kidney , endocrinology

The rising prevalence of obesity-related glomerulopathy (ORG) occurs in accordance with the rising prevalence of obesity worldwide. Clinically ORG is manifested by slowly progressing microalbuminuria that may develop to clinically evident proteinuria. Pathological characteristics of ORG include glomerular hypertrophy in the presence or absence of focal segmental glomerulosclerosis (FSGS). ORG can develop into clinically overt chronic renal insufficiency or even end-stage kidney disease. This article reviews the most important mechanisms for the development of ORG; that are abnormal renal hemodynamics, stimulation of renin-angiotensin-aldosterone system (RAAS), impairment of insulin sensetivity, ectopic lipid deposition, adipose tissue cytokine disorder and local renal micro-inflammation.

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