Preparation, Characterization and Ex vivo Permeability Study of Transdermal Apixaban O/W Nanoemulsion Based Gel | Zendy

Mustafa R. Abdulbaqi | Zendy; Nawal A. Rajab | Zendy

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Preparation, Characterization and Ex vivo Permeability Study of Transdermal Apixaban O/W Nanoemulsion Based Gel

Author(s) -

Mustafa R. Abdulbaqi,

Nawal A. Rajab

Publication year - 2020

Publication title -

iraqi journal of pharmaceutical sciences ( p-issn 1683 - 3597 e-issn 2521 - 3512)

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.122

H-Index - 1

eISSN - 2521-3512

pISSN - 1683-3597

DOI - 10.31351/vol29iss2pp214-222

Subject(s) - transdermal , permeation , ex vivo , chromatography , pulmonary surfactant , stratum corneum , chemistry , bioavailability , materials science , pharmacology , membrane , in vitro , biochemistry , medicine , pathology

This study designed to prepare ultrafine apixaban (APX) o/w nanoemulsion (NE) based gel with droplet size below 50 nm as a good method for transdermal APX delivery without using permeation enhancer, alternatively, the formulation components itself act as permeation enhancer. APX, a potent oral anticoagulant drug that selectively and directly inhibit coagulation factor Xa, was selected as a good candidate for transdermal delivery as it displays poor water solubility (0.028 mg/mL) and low bioavailability (50%). APX-NE gel was prepared using triacetin, triton-x-100 and carbitol as oil phase, surfactant and cosurfactant respectively, while Carbopol 940 used as a gelling agent. Ex vivo permeation of APX-NE gel through human stratum corneum reveal

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