Open AccessPreparation and In Vitro Permeation of Chlopheniramine Maleate (CPM) from Gel through Rat Skin
Author(s) -
Wissam S. Mahmood,
Balkis A. Kamal
Publication year - 2017
Publication title -
al-maǧallaẗ al-’irāqiyyaẗ li-l-’ulūm al-ṣaydalāniyyaẗ/iraqi journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.122
H-Index - 1
eISSN - 2521-3512
pISSN - 1683-3597
DOI - 10.31351/vol17iss2pp67-73
Subject(s) - triethanolamine , permeation , chemistry , sodium , urea , sodium alginate , chromatography , pharmacology , nuclear chemistry , medicine , membrane , biochemistry , organic chemistry , analytical chemistry (journal)
Chlopheniramine maleate ( CPM ) , is one of the H- receptor antagonist , widely used in allergic diseases ,like skin rash and pruritis .CPM 3%w/w was successfully loaded in 2%w/w sodium alginate (SA) as a gel base , and to be considered as a selected formula .It was found that the diffusion of CPM through the skin of albino rat was increased as the concentration of CPM increased from 2 %w/w sodium alginate , More over , the addition of Triethanolamine 5 % w/w, to sodium alginate 2 % w/w , loaded by CPM 3 % w/w , enhanced the amount of CPM diffuse through the skin of albino rat . Mean while the addition of PEG 1000 2% w/w , and urea 5 % w/w, separately to sodium alginate 2 % w/w , loaded by CPM 3 % w/w , hindered significantly P<0.05 the amount of the drug diffused through the skin of the rat .The selected formula of sodium alginate 2% w/w as a base loaded by CPM 3% w/w was physically acceptable , with shelf life approximately 3.3 years .
Key wards: chlopheniramine maleate , gel , skin permeation