Open AccessSome Variables Affecting the Formulation of Pentoxifylline (PTX) as a Solid Sustained Release Dosage Form
Author(s) -
Ahmed H. Hussain,
Yehia I. Khalil
Publication year - 2017
Publication title -
al-maǧallaẗ al-’irāqiyyaẗ li-l-’ulūm al-ṣaydalāniyyaẗ/iraqi journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.122
H-Index - 1
eISSN - 2521-3512
pISSN - 1683-3597
DOI - 10.31351/vol17iss1pp1-6
Subject(s) - granulation , chemistry , polymer , solvent , chromatography , dosage form , fire retardant , matrix (chemical analysis) , chloroform , nuclear chemistry , pharmacology , materials science , organic chemistry , medicine , composite material
An inert matrix that is used to control the release of (PTX) was prepared using Eudragit RL100 and RSPM types as matrix forming agent . The matrices were prepared by either dry granulation(slugging) , or wet granulation method using chloroform as a solvent evaporation vehichle. The cumulative release was adjusted by using polyvinylpyrollidone (PVP) or ethylcellulose (EC) polymers .The results indicated that both methods of preparation were valid for incorporation PTX as a sustained release granules .Moreover ,the results revealed that best polymer used was Eudragit RSPM in 3:20 polymer drug ratio .Besides to that , the results indicated that the release profiles were affected by pH- medium , PVP and EC addition as an enhancer or retardant polymer used respectively. As well as to the method of preparation .
Key words : Pentoxifylline Sustained Retease , Eudragit RS , RL .