Synthesis of Schiff Bases of Benzaldehyde and Salicylaldehyde as Anti-inflammatory Agents | Zendy

Tagreed N-A Omar | Zendy

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Synthesis of Schiff Bases of Benzaldehyde and Salicylaldehyde as Anti-inflammatory Agents

Author(s) -

Tagreed N-A Omar

Publication year - 2017

Publication title -

iraqi journal of pharmaceutical sciences ( p-issn 1683 - 3597 e-issn 2521 - 3512)

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.122

H-Index - 1

eISSN - 2521-3512

pISSN - 1683-3597

DOI - 10.31351/vol16iss2pp5-11

Subject(s) - salicylaldehyde , acetanilide , benzaldehyde , sulfonamide , chemistry , schiff base , derivative (finance) , organic chemistry , polymer chemistry , catalysis , financial economics , economics

Three Schiff bases from Benzaldehyde and Salicylaldehyde have been synthesized (A, 1and 2) and two of them (1and 2) have been tested for anti-inflammatory activity. The p-aminobenzene sulfonamide has been synthesized from acetanilide through the addition of excess chlorosulfonic acid then concentrated ammonia solution; Schiff base of this derivative (2) exhibited good level of activity against egg-white induced edema in rat hind paw, while the other tested derivative exhibited no activity. Key words: Schiff bases, sulfonamide derivatives, salicylaldehyde

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