Effect of Metformin and Antioxidant Agents on Hirsutism in Women with Polycystic Ovary Syndrome | Zendy

Mohammed A. Taher | Zendy

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Effect of Metformin and Antioxidant Agents on Hirsutism in Women with Polycystic Ovary Syndrome

Author(s) -

Mohammed A. Taher

Publication year - 2017

Publication title -

iraqi journal of pharmaceutical sciences ( p-issn 1683 - 3597 e-issn 2521 - 3512)

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.122

H-Index - 1

eISSN - 2521-3512

pISSN - 1683-3597

DOI - 10.31351/vol15iss1pp33-36

Subject(s) - hirsutism , polycystic ovary , metformin , medicine , antioxidant , oxidative stress , vitamin e , ovary , endocrinology , diabetes mellitus , insulin resistance , chemistry , biochemistry

Forty six Iraqi women with PCOS were involved in this study . They were treated with metformin alone and with antioxidant agents (vitamin E or C).It was found that all patients who treated with metformin or with combination of metformin with antioxidant agents showed significant decrease in hirsutism score. The treatment of metformin with antioxidant agents is of great benefit in treatment of hirsutism in PCOS due to that there was no worsening effect after treatment. This may indicate that antioxidant agents may participate in alleviation of hirsutism so it can be said that oxidative stress may play an important role in developing of hirsutism in PCOS.

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