Open AccessThe Prevalence and Prognostic Value of BRAFV600E Mutation in Papillary Thyroid Cancer
Author(s) -
Ala’a Al Maaitah,
Moaath Alsmady,
Shatha Dmour,
Dana Alsmady,
Ahmad Al Alwan,
Mira Younis,
Mohammad Al Shhab,
Malek Zihlif,
Heyam Awad,
Handan Ankaralı,
Nader Albsoul,
Orhan Ali̇moğlu
Publication year - 2019
Publication title -
international journal of human and health sciences
Language(s) - English
Resource type - Journals
ISSN - 2523-692X
DOI - 10.31344/ijhhs.v3i4.106
Subject(s) - medicine , papillary thyroid cancer , thyroid cancer , cancer , mutation , thyroidectomy , oncology , lymph node , retrospective cohort study , lymph node metastasis , gastroenterology , thyroid , metastasis , gene , genetics , biology
Objective: B-type Raf kinase (BRAF)V600E mutation in papillary thyroid cancer (PTC) has variable prevalence worldwide and it is hypothesized to worsen tumor prognosis. This study was conducted to investigate the prevalence of BRAFV600E mutation among PTC patients and to find out its prognostic impact measured by its association with various clinicopathologic features, recurrence, and mortality.Methods: This is a retrospective study that included 123 PTC patients who underwent thyroidectomy at Jordan University Hospital between January 2010 and December 2015. They were followed up over a mean of 18 months (range: 4-72). BRAFV600E mutation was analyzed by direct sequencing. A p value less than 0.05 was defined as statistically significant.Results: Twenty three out of 123 (18.7%) PTC patients were BRAFV600E mutation positive. BRAFV600E- mutant patients were more likely to have larger tumor size (1.8 vs 2.5 cm, p=0.040), to present with lymph node metastasis (LNM) (41.2% vs 82.4%, p=0.002), and to develop recurrence (1 vs 3, p=0.0003). Moreover, tumor recurrence which was recorded in 4 patients was significantly associated with LNM (p=0.038). Cancer-specific mortality rate was null.Conclusion: BRAFV600E mutation rate in PTC was low relative to world-wide prevalence. BRAFV600E mutation has prognostic value for PTC management. However, its cost-effectiveness should be revised. Further larger prospective studies in the region are recommended.International Journal of Human and Health Sciences Vol. 03 No. 04 October’19 Page : 223-230