Open AccessMetal- and solvent-free preparation of benzo[4,5]imidazo[1,2-a]pyrimidine derivatives catalysed by deep eutectic solvents
Author(s) -
Thanh Truc Nguyen,
Anh Vy Truong,
Hoang Phuong Tran
Publication year - 2021
Publication title -
vietnam journal of science, technology and engineering (ministry of science and technology)/vietnam journal of science, technology and engineering
Language(s) - English
Resource type - Journals
eISSN - 2615-9937
pISSN - 2525-2461
DOI - 10.31276/vjste.63(3).15-17
Subject(s) - deep eutectic solvent , choline chloride , chemistry , solvent , phenol , catalysis , yield (engineering) , organic chemistry , eutectic system , environmentally friendly , ethyl acetoacetate , metal , green chemistry , materials science , reaction mechanism , ecology , alloy , metallurgy , biology
by an acidic deep eutectic solvent from choline chloride (ChCl) and phenol via the Biginelli reaction of 2-aminobenzimidazole, ethyl acetoacetate, and aldehydes has been developed under metal- and solvent-free conditions. The desired products were obtained in moderate to good yield (49-79%) and the DESs were known as an economical and environmentally friendly catalyst.