Open AccessTwo methods for determination of a binary mixture of Amlodipine besylate and Atorvastatin calcium using dual-wavelength spectrophotometry
Author(s) -
Duc Thien Nguyen,
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Thi My Linh Nguyen,
Thi Yen Loan Le,
Diem Quynh Dieu,
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Publication year - 2022
Publication title -
tạp chí khoa học và công nghệ việt nam (b, online) (vietnam journal of science and technology - most)/tạp chí khoa học và công nghệ việt nam (điện tử)/tạp chí khoa học và công nghệ việt nam (b, print) (vietnam journal of science and technology - most)
Language(s) - English
Resource type - Journals
eISSN - 2615-9759
pISSN - 1859-4794
DOI - 10.31276/vjst.64(2).25-29
Subject(s) - repeatability , amlodipine , linear range , chromatography , absorption (acoustics) , accuracy and precision , materials science , analytical chemistry (journal) , spectrophotometry , pharmaceutical formulation , chemistry , detection limit , mathematics , medicine , statistics , blood pressure , composite material , radiology
Two simple, clear, and accurate spectrophotometric methods based on two-wavelength selections, were developed for the simultaneous determination of Amlodipine besylate (AML) and Atorvastatin calcium (ATO) in tablet dosage forms. The ratio difference method uses amplitudes between 238 and 288 nm. The measured amplitudes for the parameters: linear range 4-40 μg/ml; precision for AML is 100.22±0.7856, repeatability is 0.9122, precision for ATO is 100.12±0.6439, repeatability is 0.8968. The absorption ratio method using two wavelengths is 221 and 238 nm. The absorption rate method for parameters: linear range 4-40 μg/ml; precision for AML is 100.6±0.9562, repeatability is 1.0124, precision for ATO is 100.86±0.8596, repeatability is 1.1045. Both quantitative methods showed that AML and ATO could be quantified in their mixtures without any extraction at all. The absorption ratio method exhibited quick, simple applicability to both laboratory and commercial drug mixtures.