Open AccessHypoglycemic effect of leaf extract of Pseuderanthemum crenulatum leaves in an alloxan-induced diabetic mice
Author(s) -
Thi Bich Duong,
AUTHOR_ID,
The Anh Du,
Kim Ngoc Tri,
Huu Phuc Nguyen,
Xuan Linh Nguyen,
Thanh Hung Banh,
Ngoc Trung Dung Huynh,
AUTHOR_ID,
AUTHOR_ID,
AUTHOR_ID,
AUTHOR_ID,
AUTHOR_ID,
AUTHOR_ID
Publication year - 2022
Publication title -
tạp chí khoa học và công nghệ việt nam (b, online) (vietnam journal of science and technology - most)/tạp chí khoa học và công nghệ việt nam (điện tử)/tạp chí khoa học và công nghệ việt nam (b, print) (vietnam journal of science and technology - most)
Language(s) - English
Resource type - Journals
eISSN - 2615-9759
pISSN - 1859-4794
DOI - 10.31276/vjst.64(2).21-24
Subject(s) - acarbose , alloxan , hypoglycemia , gliclazide , toxicity , diabetes mellitus , acute toxicity , oral administration , pharmacology , ic50 , ethanol , medicine , positive control , chemistry , traditional medicine , in vitro , endocrinology , biochemistry
In this study, the hypoglycaemic effects of ethanol extracts from Pseuderanthemum crenulatum leaves were investigated. The evaluated trials included: in vitroα-glucosidase inhibitory activity; oral glucose tolerance test in normoglycemic mice; hypoglycemia in an alloxan-induced diabetic mice model, and oral toxicity assay. The results showed that the ethanol extract of P. crenulatumleaves was able to inhibit α-glucosidase enzyme at IC50=66.01 μg/ml, 1.8 times higher than acarbose control (IC50 was 122.2 μg/ml). After 21 days of using leaf extract of P. crenulatum (1 g/kg) to treat diabetic mice, the blood glucose was reduced by 42.02%. This result was equivalent to gliclazide (10 mg/kg) which reduced the blood glucose of diabetic mice by 41.78%. The oral toxicity test results at a dose of 5 g/kg equivalent to 357 g of fresh leaf/kg after 72 hours was not exhibited acute oral toxicity in mice. In summary, there is a need for more studies on the ability of P. crenulatum leaves to treat diabetes.