Open AccessEnhancement of drug delivery across the skin barrier using iontophoresis technique: pros, cons, and novel findings from representative studies
Author(s) -
Thi Hong Nguyen,
Quoc Anh Vo
Publication year - 2021
Publication title -
tạp chí khoa học và công nghệ việt nam (b, online) (vietnam journal of science and technology - most)/tạp chí khoa học và công nghệ việt nam (điện tử)/tạp chí khoa học và công nghệ việt nam (b, print) (vietnam journal of science and technology - most)
Language(s) - English
Resource type - Journals
eISSN - 2615-9759
pISSN - 1859-4794
DOI - 10.31276/vjst.63(9).39-43
Subject(s) - iontophoresis , transdermal , medicine , nanotechnology , instrumentation (computer programming) , skin barrier , risk analysis (engineering) , biomedical engineering , computer science , pharmacology , materials science , dermatology , radiology , operating system
Iontophoresis has been utilised to deliver medications in physical therapy for a long time, but its applications in treating diseases are still limited. This stemmed partly from its complicated and unsafe instrumentation as well as insufficient scientific evidence. Over the past decade, however, the design and safety aspects of iontophoresis devices have been dramatically improved. More importantly, various optimistic results were revealed from many scientific studies, especially its potential to actively transport large molecules and nanoparticles across the skin barrier that attracts great attention from both academia and industry. This paper aimed to review the advantages and disadvantages of the technique and representative transdermal enhancement studies using iontophoresis.