Open AccessAn Expeditious Route for the Synthesis of Thiadiazolo - Pyrimidin - 2- Thiones Using Microwaves
Author(s) -
A. D. Mishra
Publication year - 2010
Language(s) - English
Resource type - Journals
ISSN - 2091-0916
DOI - 10.3126/tuj.v27i1-2.26347
Subject(s) - ethyl acetoacetate , yield (engineering) , microwave irradiation , chemistry , microwave , dry media reaction , condensation , combinatorial chemistry , condensation reaction , catalysis , organic chemistry , nuclear chemistry , materials science , kinetics , computer science , telecommunications , physics , quantum mechanics , reaction rate constant , order of reaction , metallurgy , thermodynamics
A series of 1-(1,3,4-thiadiazolo)-2-thioxo-pyrimidines 4a-g are synthesized by the condensation of monosubsituted thioureas la-g, ethyl acetoacetate 2 and arylaldehyde 3 in dry media using microwave irradiation. The reactions are completed in very short time with high yield. The use of inorganic solid supports has been proved as an alternative mean of synthetic media.