Open AccessLack of Pharmacokinetic Interaction between Enalapril and Amlodipine with Phenytoin in Rhesus monkeys
Author(s) -
Garg Sk,
DK Badyal,
Sisir K. Majumdar
Publication year - 2004
Publication title -
nepalese heart journal/nepalese heart journal
Language(s) - English
Resource type - Journals
eISSN - 2382-5464
pISSN - 2091-2978
DOI - 10.3126/njh.v3i3.26143
Subject(s) - enalapril , amlodipine , phenytoin , pharmacokinetics , pharmacokinetic interaction , pharmacology , drug interaction , plasma concentration , medicine , chemistry , endocrinology , epilepsy , blood pressure , angiotensin converting enzyme , psychiatry
A cross-over and multiple dose study was carried out to find out possible pharmacokinetic interactions between phenytoin (DPH 35 ma/kg; p.o.) and antihypertensives enalapril (1.6 mg/kg; p.o.) and amlodipine (0.4 mg/kg, p.o.) in rhesus monkeys. Neither the plasma concentrations nor the pharmacokinetic parameters of DPH were altered by coadministration of enalapril or amlodipine, suggesting that enalapril and amlodipine can be safely administered to epileptic patients receiving phenytoin.