Lack of Pharmacokinetic Interaction between Enalapril and Amlodipine with Phenytoin in Rhesus monkeys | Zendy

Satish K. Garg | Zendy; DK Badyal | Zendy; Sisir K. Majumdar | Zendy

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Lack of Pharmacokinetic Interaction between Enalapril and Amlodipine with Phenytoin in Rhesus monkeys

Author(s) -

Satish K. Garg,

DK Badyal,

Sisir K. Majumdar

Publication year - 2004

Publication title -

nepalese heart journal

Language(s) - English

Resource type - Journals

eISSN - 2382-5464

pISSN - 2091-2978

DOI - 10.3126/njh.v3i3.26143

Subject(s) - enalapril , amlodipine , phenytoin , pharmacokinetics , pharmacokinetic interaction , pharmacology , drug interaction , plasma concentration , medicine , chemistry , endocrinology , epilepsy , blood pressure , angiotensin converting enzyme , psychiatry

A cross-over and multiple dose study was carried out to find out possible pharmacokinetic interactions between phenytoin (DPH 35 ma/kg; p.o.) and antihypertensives enalapril (1.6 mg/kg; p.o.) and amlodipine (0.4 mg/kg, p.o.) in rhesus monkeys. Neither the plasma concentrations nor the pharmacokinetic parameters of DPH were altered by coadministration of enalapril or amlodipine, suggesting that enalapril and amlodipine can be safely administered to epileptic patients receiving phenytoin.

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