Open AccessAugmented Post-Induction Therapy for Children with High-Risk Acute Lymphoblastic Leukemia and a Slow Response to Initial Therapy
Author(s) -
Asifur Rahman,
Subhash K. Gupta,
Md. Abdul Mannan,
Kamrun Nahar
Publication year - 2014
Publication title -
kathmandu university medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.166
H-Index - 25
eISSN - 1812-2078
pISSN - 1812-2027
DOI - 10.3126/kumj.v10i4.10996
Subject(s) - medicine , regimen , induction chemotherapy , chemotherapy , chemotherapy regimen , randomized controlled trial , pediatrics , cohort , acute lymphocytic leukemia , surgery , leukemia , lymphoblastic leukemia
Children with high-risk acute lymphoblastic leukemia (ALL) who have a slow response to initial chemotherapy (more than 25 percent blasts in the bone marrow on day 7) have a poor outcome despite intensive therapy. We conducted a randomized trial in which such patients were treated with either an augmented intensive regimen of post-induction chemotherapy or a standard regimen of intensive post-induction chemotherapy.