z-logo
HomeZAIABlog
open-access-imgOpen Access
Expressions of HPV 16-E6 in esophageal carcinoma and it’s clinical significance
Author(s) -
Xi Zhao,
Rajina Sahi,
Yong Zhao,
Jun Wang,
Chunhui Li
Publication year - 2015
Publication title -
journal of pathology of nepal
Language(s) - English
Resource type - Journals
eISSN - 2091-0797
pISSN - 2091-0908
DOI - 10.3126/jpn.v5i9.13786
Subject(s) - medicine , esophageal cancer , esophageal squamous cell carcinoma , immunohistochemistry , pathology , metastasis , carcinoma , lymph node metastasis , esophageal neoplasm , clinical significance , esophagus , cell , oncology , cancer , biology , genetics

Background?Gastrointestinal cancer is the most common malignant tumor in China. This research aims to explore the association between HPV16-E6 protein and esophageal squamous cell carcinoma.

Materials and Methods: SP immunohistochemical method was used to examine the expression of HPV 16-E6 in 50 cases of esophageal squamous cell carcinoma, 10 cases of normal esophageal squamous cell and 10 cases of adjacent tissue.

Results: The expressions of HPV 16-E6 was significantly higher in esophageal carcinoma than in normal esophageal mucosa and in adjacent tissue. The expressions of HPV 16-E6 had correlation with invasive depth (P<0.05), but not with patient age, lymph node metastasis, tumor size (P>0.05).

Conclusion: HPV 16-E6 can promote the growth and metastasis of esophageal squamous cell carcinoma and can be a prognostic factor of esophageal squamous cell carcinoma.

Journal of Pathology of Nepal (2015) Vol. 5, 752-755

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here
Empowering knowledge with every search

About

AboutCareersPublisher PartnersContact Us

Learn

FAQsBlogTerms of UsePrivacy Policy

Discover

Explore

Copyright Knowledge E © 2025. All Rights Reserved.