Open AccessNeonatal Screening for Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency in Eastern India
Author(s) -
Satyam Mukherjee,
Ashish Mallige,
Anupama Chowdhry,
Amit Devgan,
Brajesh Kumar Singh,
Bhasker Mukherjee,
Subhash Chandra Shaw
Publication year - 2021
Publication title -
journal of nepal paediatric society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.13
H-Index - 8
eISSN - 1990-7982
pISSN - 1990-7974
DOI - 10.3126/jnps.v41i3.37153
Subject(s) - medicine , jaundice , umbilical cord , cord blood , incidence (geometry) , pediatrics , population , asphyxia , obstetrics , prospective cohort study , glucose 6 phosphate dehydrogenase deficiency , population study , observational study , cord , surgery , immunology , physics , environmental health , optics
The overall magnitude of the frequency of G6PD deficiency ranges between 0 to 10 percent in the Indian population. This prospective study was planned to estimate the prevalence of G6PD deficiency in newborn population born in a tertiary care centre in Eastern India.Methods: This prospective observational study was undertaken among all consecutively delivered neonates born in a tertiary care teaching hospital of Eastern India, between Apr 2016 and Oct 2017. Prematurity less than 32 weeks and perinatal asphyxia requiring extensive resuscitation were excluded from the study. Umbilical cord blood samples were collected in a EDTA containers, drawn from the placental side of the umbilical cord incised while severing it at the time of birth. The G6PD levels were estimated quantitatively based on ultraviolet (UV) method by quantitative sphectrophotometric assay using ILab 650 fully automated analyzer. All babies wherein the cord blood G6PD levels was less than 6.95 mU/g of Hb was taken as deficient. Results: Mean (SD) of G6PD at birth was 12.56 (3.45) mU/g of Hb. Out of 1037 neonates, five were found to be G6PD deficient. There was increased incidence of neonatal jaundice requiring phototherapy in G6 PD deficient neonates, and it was statistically significant.Conclusion: The prevalence of G6PD deficiency was 0.48% in term and late preterm neonates as assessed quantitatively in cord blood