Open AccessTransient Abnormal Myelopoiesis in a Neonate without Down Syndrome
Author(s) -
Rupesh Shrestha
Publication year - 2018
Publication title -
journal of nepal paediatric society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.13
H-Index - 8
eISSN - 1990-7982
pISSN - 1990-7974
DOI - 10.3126/jnps.v37i3.19186
Subject(s) - medicine , trisomy , respiratory distress , down syndrome , myelopoiesis , clone (java method) , phenotype , pathology , immunology , pediatrics , surgery , haematopoiesis , biology , genetics , dna , stem cell , psychiatry , gene
Transient abnormal myelopoiesis (TAM) also known as transient myeloproliferative disorder (TMD), a unique transient neonatal preleukaemic disorder characterized by clonal proliferation of megakaryoblasts, has been usually described to be associated with Down syndrome neonates. However, there are case reports of it occurring in neonates without Down phenotype, who are either mosaic for trisomy 21 or have trisomy 21 restricted to leukemic clone. This case report presents a case of TAM in a phenotypically normal neonate who presented in respiratory distress with features of tumour lysis syndrome (TLS) immediately after birth who was treated symptomatically and had spontaneous remission within three months.