Open AccessExpressions of HPV 16-E6 in Esophageal Carcinoma and its Clinical Significance
Author(s) -
Xing Zhao,
Rajina Sahi,
Yong Zhao,
Ju Wang,
Chunhui Li
Publication year - 2015
Publication title -
journal of college of medical sciences-nepal
Language(s) - English
Resource type - Journals
eISSN - 2091-0673
pISSN - 2091-0657
DOI - 10.3126/jcmsn.v10i4.12970
Subject(s) - medicine , esophageal squamous cell carcinoma , immunohistochemistry , esophageal cancer , human papilloma virus , lymph node metastasis , carcinoma , metastasis , esophageal neoplasm , pathology , cell , cervix , clinical significance , oncology , cancer , cervical cancer , biology , genetics
Background and Objective: The role of (Human Papilloma Virus) HPV in cancer of certain anatomical location, such as cervix, has been widely recognized. The present study was conducted to explore the association between HPV 16-E6 protein and esophageal squamous cell carcinoma.Methods: SP immunohistochemical method was used to examine the expression of HPV 16-E6 in 50 cases of esophageal squamous cell carcinoma, 10 cases of normal esophageal squamous cell and 10 cases of adjacent tissue.Results: The expression of HPV 16-E6 was significantly higher in esophageal carcinoma than in normal esophageal mucosa and in adjacent tissue. The expressions of HPV 16-E6 had significant correlation with invasive depth (P 0.05).Conclusion: HPV 16-E6 can promote the growth and metastasis of esophageal squamous cell carcinoma and can be a prognostic factor of esophageal squamous cell carcinoma.JCMS Nepal 2014; 10(4):1-5