Open AccessExpressions of HPV 16-E6 in esophageal carcinoma and its clinical significance
Author(s) -
Xing Zhao,
Rajina Sahi,
Yong Zhao,
Jun Wang,
Chunhui Li
Publication year - 2017
Publication title -
journal of advances in internal medicine
Language(s) - English
Resource type - Journals
eISSN - 2091-1440
pISSN - 2091-1432
DOI - 10.3126/jaim.v4i2.16897
Subject(s) - esophageal squamous cell carcinoma , immunohistochemistry , lymph node metastasis , medicine , carcinoma , metastasis , pathology , cell , esophageal neoplasm , basal cell , clinical significance , esophagus , oncology , biology , cancer , genetics
Aim: The aim of the study was to explore the association between HPV16-E6 protein and esophageal squamous cell carcinoma.Methods: SP immunohistochemical method was used to examine the expression of HPV 16-E6 in 50 cases of esophageal squamous cell carcinoma, 10 cases of normal esophageal squamous cell and 10 cases of adjacent tissue.Result: The expressions of HPV 16-E6 was significantly higher in esophageal carcinoma than in normal esophageal mucosa and in adjacent tissue. The expressions of HPV 16-E6 had a significant correlation with invasive depth (P 0.05).Conclusion: HPV 16-E6 can promote the growth and metastasis of esophageal squamous cell carcinoma and can be a prognostic factor of esophageal squamous cell carcinoma.