Expressions of HPV 16-E6 in esophageal carcinoma and its clinical significance | Zendy

Xing Zhao | Zendy; Rajina Sahi | Zendy; Yu-Yang Zhao | Zendy; Jun Wang | Zendy; Chunhui Li | Zendy

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Expressions of HPV 16-E6 in esophageal carcinoma and its clinical significance

Author(s) -

Xing Zhao,

Rajina Sahi,

Yu-Yang Zhao,

Jun Wang,

Chunhui Li

Publication year - 2017

Publication title -

journal of advances in internal medicine

Language(s) - English

Resource type - Journals

eISSN - 2091-1440

pISSN - 2091-1432

DOI - 10.3126/jaim.v4i2.16897

Subject(s) - esophageal squamous cell carcinoma , immunohistochemistry , lymph node metastasis , medicine , carcinoma , metastasis , pathology , cell , esophageal neoplasm , basal cell , clinical significance , esophagus , oncology , biology , cancer , genetics

Aim: The aim of the study was to explore the association between HPV16-E6 protein and esophageal squamous cell carcinoma.Methods: SP immunohistochemical method was used to examine the expression of HPV 16-E6 in 50 cases of esophageal squamous cell carcinoma, 10 cases of normal esophageal squamous cell and 10 cases of adjacent tissue.Result: The expressions of HPV 16-E6 was significantly higher in esophageal carcinoma than in normal esophageal mucosa and in adjacent tissue. The expressions of HPV 16-E6 had a significant correlation with invasive depth (P 0.05).Conclusion: HPV 16-E6 can promote the growth and metastasis of esophageal squamous cell carcinoma and can be a prognostic factor of esophageal squamous cell carcinoma.

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