Open AccessRepurposing Artemisia annua L. Flavonoids, Artemisinin and Its Derivatives as Potential Drugs Against Novel Coronavirus (SARS –nCoV) as Revealed by In-Silico Studies
Author(s) -
K V S Hari Kumar,
Apoorva,
Lakee Sharma,
Neha Pandey,
Raj Kumar Meena,
Shashi Pandey-Rai
Publication year - 2020
Publication title -
international journal of applied sciences and biotechnology
Language(s) - English
Resource type - Journals
ISSN - 2091-2609
DOI - 10.3126/ijasbt.v8i4.33667
Subject(s) - artemisia annua , artemisinin , in silico , covid-19 , traditional medicine , drug repositioning , repurposing , coronavirus , virology , pharmacology , drug discovery , drug , biology , medicine , malaria , plasmodium falciparum , immunology , bioinformatics , infectious disease (medical specialty) , disease , biochemistry , ecology , pathology , gene , outbreak
Coronavirus-induced COVID-19, a highly contagious respiratory illness first originated from Wuhan city of Hubei province, China, and has affected 235 countries across the globe. The COVID-19 is mainly transmitted by the droplets of an infected person when they cough, sneeze, or exhale. Currently, there are no specific drugs licensed for the effective treatment or prevention of COVID-19 and the treatment is mainly focused on controlling symptoms. Identification of small bioactive plant molecules that specifically target whole viral replication apparatus have great potential towards the development of antiviral drug discovery. This communication describes our current understanding of SARS-nCoV interaction with some herbal bioactive compounds of A. annua including sesquiterpenes, flavonoids and phenolics using in silico approach.
Int. J. Appl. Sci. Biotechnol. Vol 8(4): 374-393