Open AccessSynthesis of antioxidative anthraquinones as potential anticancer agents
Author(s) -
Richa Gupta,
Ganesh M. S. Thakuri,
Gan B. Bajracharya,
R. N. Jha
Publication year - 2021
Publication title -
bibechana
Language(s) - English
Resource type - Journals
ISSN - 2382-5340
DOI - 10.3126/bibechana.v18i2.31234
Subject(s) - anthraquinones , emodin , anthraquinone , chemistry , dpph , bacillus subtilis , antioxidant , traditional medicine , organic chemistry , biochemistry , bacteria , biology , botany , medicine , genetics
Antioxidant and antibacterial activities of natural anthraquinones namely chrysophanol (1) and emodin (2), and synthesized anthraquinones viz. 2-methylanthraquinone (3), anthraquinone (4), 2-bromoanthraquinone (5), rubiadin (6), chrysophanol diacetate (7), rubiadin diacetate (8) and 1,8-dimethoxy-3-methylanthraquinone (9) were investigated. Anthraquinones 9, 3, 6, 5 and 2 exhibited a high DPPH• radical scavenging capacity (IC50 = <500 μg/mL) showing their therapeutic potentiality for the treatment of cancers. These anthraquinones 1-9 have also displayed a weak to moderate antibacterial activity against Bacillus subtilis. Chrysophanol diacetate (7) including emodin (2) have been appeared as the valuable antibacterials.
BIBECHANA 18 (2) (2021) 143-153