Circulating interleukins (IL6)-An early predictor of insulin resistance

Background: Obesity is an increasing health concern that is highly correlated with the risk of developing insulin resistance and type-2 diabetes The insulin resistance represents an important association between obesity and the morbidities that lead concomitantly to increase in visceral adiposity. The more resistant to insulin the individual is, the higher the risk for the development of type-2 diabetes and cardiovascular disease. The purpose of this study was to assess the correlation between insulin resistance and the production of cytokines (IL6) and to establish the relations between interleukins IL-6 and  various anthropometric measurementsMaterial and Methods: A cross-sectional study was carried on 100 healthy individuals (55 males and 45 females)  aged between 18-25  years were enrolled after obtaining their written consent in Department of Physiology, KGMU. All the subjects were evaluated anthropometric: Body mass index (BMI),  Waist circumference (WC),   Hip circumference (HC), Waist hip ratio and Waist height ratio as per standard protocol. Metabolic measures ( Fasting glucose and insulin) were done using commercial kit.  Insulin  resistance was measured  using homeostasis model.Results:  There was a significant positive correlation between interleukin 6 and fasting serum insulin (r=0.56, p=0.001) & HOMA IR (r=0.57, p=0.001). Correlation between anthropometric measure and Interleukins (IL-6) was also observed to be positive and mild.Conclusion: A significant positive correlation was seen between IL-6 and fasting serum insulin and HOMA-IR indicating  IL 6 as a  good predictive marker for insulin resistance.Asian Journal of Medical Sciences Vol.7(6) 2016 20-25