Open AccessChanges in post-operative renal function and coagulation profile after hydroxyethyl starch administration in patients undergoing orthopedic hip surgery under spinal anesthesia
Author(s) -
Kirti Kamal,
Monika Bhandari,
Priyanka Bansal,
Geeta Ahlawat,
Renu Bala,
Diya Aggrawal
Publication year - 2021
Publication title -
asian journal of medical sciences
Language(s) - English
Resource type - Journals
ISSN - 2091-0576
DOI - 10.3126/ajms.v12i11.39496
Subject(s) - medicine , orthopedic surgery , hydroxyethyl starch , hypovolemia , anesthesia , hip surgery , surgery , renal function , prospective cohort study , anesthesiology , arthroplasty
Background: Hydroxyethyl starch solutions which have been introduced some three decades ago, have been extensively used for treatment of intraoperative hypovolaemia.Aims and Objectives: The present prospective study was conducted to study changes in post-operative renal function and coagulation profile in patients undergoing orthopedic hip surgery under spinal anesthesia after coloading with 6% HES 130/0.4.Materials and Methods: Seventy patients, aged between 50 and 80 years, of either sex, belonging to ASA physical Status I and II, scheduled for orthopedic hip surgery under spinal anesthesia were included in the study. As per the group allocation, coloading was done with 7.5 mlkg-1 of either Group RL or 6% 130/0.4 Group HES during the 1st h of surgery. Venous samples were withdrawn before the day of surgery, on the day of surgery, and on the 3rd day of surgery.Results: No statistically significant difference between renal and coagulation profile was found among groups.Conclusion: Thus, we recommend using tetrastarch (6% HES 130/0.4) for intraoperative hypovolemia in elderly patients with normal renal function and coagulation profile undergoing orthopedic hip surgery.