Open AccessLipoprotein-associated phospholipase A2 in relation to lipid markers: A pan-India correlation study
Author(s) -
Sandhya Iyer,
Rajkumar Kushawaha,
Prachi Sinkar,
Sivakumar Selvaraj,
Amruta Velumani
Publication year - 2019
Publication title -
asian journal of medical sciences
Language(s) - English
Resource type - Journals
ISSN - 2091-0576
DOI - 10.3126/ajms.v10i3.22791
Subject(s) - lipoprotein associated phospholipase a2 , medicine , cholesterol , lipid profile , cohort , phospholipase a2 , lipoprotein , endocrinology , risk factor , cohort study , correlation , gastroenterology , biology , biochemistry , enzyme , geometry , mathematics
Background: Conventional serum markers are routinely recommended to assess heart health. However, many new biochemical markers like lipoprotein-associated phospholipase A2 (Lp-PLA2) has been studied as an efficient cardiac risk marker. Our report is an attempt to present correlation between traditional lipid markers and Lp-PLA2 in a pan-India cohort.
Materials and Methods: The study cohort included a total of 10347 pan-Indians including 5945 males and 4402 females respectively. The serum lipid parameters estimated include triglycerides, LDL- and HDL-cholesterol as well as total cholesterol by the technology of photometry.
Results: The frequency of high Lp-PLA2 detected in our study was 6.4% and the frequency between males at 9.3% and females at 2.5% was detected to be significant at p<0.0001. Linear regression analysis detected significant positive association of high Lp-PLA2 with LDL-cholesterol and total cholesterol at p<0.05, while the trend with HDL-cholesterol was also significant. However, Lp-PLA2 as an independent marker was not detected to be significant in relation to the lipid indices studied.
Conclusion: Though Lp-PLA2 has been associated with risk factor for acute coronary crisis, its clinical value remains controversial. Our report though detected significant association of Lp-PLA2 with various lipid parameters, independent value remains questionable.