Open AccessIn vivo analgesic and healing activities of stem bark extracts of Gardenia ternifolia Schumach. & Thonn
Author(s) -
Sylla Tahiri,
Dongui Bini Kouamé
Publication year - 2021
Publication title -
the journal of phytopharmacology
Language(s) - English
Resource type - Journals
ISSN - 2320-480X
DOI - 10.31254/phyto.2021.10612
Subject(s) - medicine , wound healing , analgesic , traditional medicine , gardenia , in vivo , achyranthes aspera , surgery , pharmacology , biology , traditional chinese medicine , alternative medicine , pathology , microbiology and biotechnology
In Ivory Coast, medicinal plants have always been used traditionally to promote wounds repairs. They have great potential for wound healing by promoting the speed of wound healing with less pain, discomfort and patient healing. The plant Gardenia ternifolia belongs to the family Rubiaceae. The macerated stem bark or the paste obtained is also used against bites snake, sexual impotence, hemorrhoids, healing wound, injury, and tooth decay. Gardenia ternifolia was extracted in aqueous and ethanol to evaluate acetic acid-induced writhing test to detect the peripheral analgesic activity of the extracts in mice. AEGT and EEGT showed reduced number of writhes which are significant compared to control (Acetaminophen). The results obtained support the use of Gardenia ternifolia in painful conditions acting peripherally. The healing activity of Gardenia ternifolia was also evaluated in the second part of the research. AEGT_50% and EEGT_50% ointments treated group showed a significant reduction in the wound breaking strength in incision type of wound model and significant increase in epithelization period and reduction in percentage of wound area in excision type of wound model as compared to control group treated with simple ointment.