Open AccessEvaluation of acute oral toxicity of a herbal rumenotoric and stomachic
Author(s) -
SW Hajare,
Ranjit Suresh Ingole,
Maheshkumar V. Ingawale,
Vivek Borekar,
Ravikanth Kotagiri,
Bhaskar Ganguly
Publication year - 2021
Publication title -
the journal of phytopharmacology
Language(s) - English
Resource type - Journals
ISSN - 2320-480X
DOI - 10.31254/phyto.2021.10501
Subject(s) - indigestion , anorexia , toxicity , medicine , flatulence , acute toxicity , physiology , impaction , oral administration , livestock , traditional medicine , toxicology , pharmacology , biology , surgery , ecology
Maintaining optimum digestive functions is crucial for achieving health and profitability in livestock enterprises. However, the efficiency of these functions is upset by common problems such as indigestion, anorexia, flatulence, ruminal stasis and impaction. Pachoplus™ (M/s Ayurvet Limited, India) is a polyherbal rumenotoric, carminative and stomachic that helps to achieve and restore optimum digestive functions in livestock. A study was undertaken to evaluate the potential of Pachoplus™ to elicit acute oral toxicity as per OECD 423 guidelines. Nine non-pregnant, nulliparous, adult female Swiss albino mice were used for the study. The animals were observed for the manifestation of toxic effects and mortality after the oral administration of the test substance. Toxicity was evaluated on the basis of changes in body weight, overt signs of toxicity, gross and histological appearances of vital organs, and blood biochemistry. Pachoplus™ was found safe for oral use as no toxic effects or mortalities were observed till day 14