Open AccessEffect of concurrent exposure of toxic concentrations of lead and endosulfan on oxidative stress indices in rats
Author(s) -
Ranganathan,
Malik Jk,
Rao Gs
Publication year - 2021
Publication title -
the journal of phytopharmacology
Language(s) - English
Resource type - Journals
ISSN - 2320-480X
DOI - 10.31254/phyto.2021.10308
Subject(s) - oxidative stress , endosulfan , catalase , chemistry , lipid peroxidation , superoxide dismutase , lead acetate , toxicity , glutathione , toxicology , lead exposure , zoology , biochemistry , medicine , pesticide , biology , enzyme , organic chemistry , cats , agronomy
The effect of concurrent exposure of toxic concentrations of lead and endosulfan were evaluated on oxidative stress parameters in male wistar rats. Group I served as untreated control whereas Group II received drinking water containing lead as lead acetate @1000 ppm (Pb1000). Group III was exposed to feed containing technical grade endosulfan @ 100 ppm (E100). Group IV was exposed to Pb (1000) +E (100). All the treatments were given daily for 28 days. Combination of lead and endosulfan modified the indices of oxidative stress in the parameters such as lipid peroxidation, reduced glutathione, superoxide dismutase and catalase in rats as compared to their individual compounds. The results suggest that the combination of these individual compounds may have the potential to modify oxidative stress produced by single compounds in male rats