Open AccessAnti-nociceptive potentials of methanol extract of Cassia alata in experimental animals
Author(s) -
Muhammed Nafiu Negedu,
Saidi Odoma,
Idowu Olumorin Owemidu,
Catherine Atede,
Sanni Momoh
Publication year - 2020
Publication title -
the journal of phytopharmacology
Language(s) - English
Resource type - Journals
ISSN - 2320-480X
DOI - 10.31254/phyto.2020.9514
Subject(s) - cassia , nociception , acetic acid , traditional medicine , tramadol , pharmacology , chemistry , medicine , analgesic , traditional chinese medicine , biochemistry , receptor , alternative medicine , pathology
Cassia alata has been used as an agent for wound healing, anti-bacteria and pain in African traditional medicine. In this study, we aim to investigate the anti- nociceptive properties of Cassia alata to scientifically justify this folkloric claim. Thermal (tail flick test) and chemical (acetic acid induced writhing test) models of nociception were employed, animals were divided into five groups (n=5), the control group was treated with 1 mL/kg of distilled water, reference group received Tramadol 50 mg/kg, while the test groups received graded doses (125,250 and 500 mg/kg) plant extract. The extract produced dose dependent inhibition of the acetic acid in the chemical test. In the thermal test, the extract also dose dependently increased the withdrawal latency as compared to the control. This study showed that the methanol extract of Casia alata leaf produced anti-nociception in models of chemical and thermal pain which justifies its folkloric claim for the treatment of pain.