Open AccessIn vitro anti-inflammatory activity of aqueous extract of Albizia lebbeck leaf (l.)
Author(s) -
Kamala Lakshmi B,
S. Valarmathi
Publication year - 2020
Publication title -
the journal of phytopharmacology
Language(s) - English
Resource type - Journals
ISSN - 2320-480X
DOI - 10.31254/phyto.2020.9511
Subject(s) - phytochemical , tannin , saponin , traditional medicine , glycoside , flavonoid , in vitro , chemistry , haemolysis , anti inflammatory , alkaloid , houttuynia cordata , aqueous solution , chromatography , pharmacology , medicine , food science , biochemistry , stereochemistry , antioxidant , organic chemistry , alternative medicine , pathology , extraction (chemistry) , immunology
Albizia lebbeck (L.) Benth is an important traditional tree found throughout India. All part of this tree is considered as folk medicine and used for treatment of various disease. Current research work was carried out to identify the bioactive compound by phytochemical screening and to evaluate anti-inflammatory potential of aqueous leaf extract of A. lebbeck. The phytochemical screening of the leaf of A. lebbeck shows the presence of alkaloid, flavonoid, tannin, phenol, saponin, glycoside and free amino acid. The maximum inhibition of protein denaturation was found to be 78.06±0.5% at 500 µg/mL concentration and its IC₅₀ was 330 µg/mL concentration. The maximum inhibition in membrane stabilization was found to be 74.09±0.33% at 500 µg/mL concentration and its IC₅₀ was 440 µg/mL concentration. The maximum protection in hypotonicity induced haemolysis shows about 69.34±0.38% at 500 µg/mL concentration and its IC₅₀ was 400 µg/mL concentration. In vitro assay shows the moderate activity of anti-inflammatory in aqueous extract of A. lebbeck, when compared with the standard.