Open AccessIn-vitro evaluation of Scoparia dulcis Linn. for anti – urolithiatic activity
Author(s) -
Hima Sasidharan,
Suma V Mallya,
S. Prabhu,
Koppala Narayana Sunil Kumar
Publication year - 2018
Publication title -
the journal of phytopharmacology
Language(s) - English
Resource type - Journals
ISSN - 2320-480X
DOI - 10.31254/phyto.2018.7309
Subject(s) - chemistry , in vivo , traditional medicine , pharmacology , dissolution , aqueous solution , chromatography , medicine , biology , organic chemistry , microbiology and biotechnology
Urolithiasis is a complex process that occurs from series of several physicochemical event including super-saturation, nucleation, growth, aggregation and retention within the kidneys. Data from invitro, in- vivo and clinical trials reveal that phytotherapeutic agents could be useful as either alternative or an adjunct therapy in the management of Urolithiasis. Scoparia dulcis (L.) have been reported to possess antiurolithiatic property by various folk lore practitioners. Methods: The in- vitro antiurolithiatic study of the whole plant of S. dulcis (L). through titrimetric and turbidity method to check their potential in dissolving calcium oxalate crystals using Cystone as the standard compound Result: The aqueous extract showed relatively higher dissolution of 66.96% of stones than the alcoholic extract. The turbidity showed by the alcohol extract and the aqueous extract of test drug (S. dulcis (L).) was highly significant compared to the standard (Cystone)