Open AccessMadhuca longifolia water extract revealed protective effect against MES, PTZ and Li-pilocarpine induced epilepsy
Author(s) -
Chandrakant V Thakare,
Chandrashekhar Upasani
Publication year - 2018
Publication title -
the journal of phytopharmacology
Language(s) - English
Resource type - Journals
ISSN - 2320-480X
DOI - 10.31254/phyto.2018.7307
Subject(s) - pilocarpine , epilepsy , phytochemical , pharmacology , medicine , aqueous extract , chemistry , antiepileptic drug , traditional medicine , psychiatry
Objective: Present study was designed to screen the antiepileptic property of aqueous extract of Madhucalongifolia (AqML) in laboratory animals. Materials and methods: Rat and mice were divided in different groups. Antiepileptic activity was tested by using maximal electric shock (MES), Pentylenetertrazole (PTZ) and lithium pilocarpine (Li-Pilocarpine) models. Treatment group of animals were received AqML at 100, 200 and 400 mg/kg p.o. for 7 days. At the end of treatment period, different parameters related of antiepileptic action were observed. Result: Preliminary phytochemical investigation revealed the presence of carbohydrate, protein, amino acid and alkaloids. Animals treatment with AqML showed significant (p<0.05) antiepileptic activity in MES, PTZ and li-pilocarpine screening models. In all the screening models AqML showed dose dependant prevention in seizure was observed and of them dose 400mg/kg p.o. was found to be very significant (p<0.05) antiepileptic effect. Conclusion: The result revealed that AqML at 400 mg/kg p.o. possesses antiepileptic activity in MES, PTZ and Li-pilocarpine models