Open AccessAllablanckia floribunda hypotensive activity on ethanol induced hypertension in rats
Author(s) -
Danielle Claude Bilanda,
Paul Désiré Djomeni Dzeufiet,
Orelien Mtopi Bopda,
P. Kamtchouing,
Théophile Dimo
Publication year - 2018
Publication title -
the journal of phytopharmacology
Language(s) - English
Resource type - Journals
ISSN - 2320-480X
DOI - 10.31254/phyto.2018.7208
Subject(s) - malondialdehyde , oxidative stress , chemistry , superoxide dismutase , kidney , lipid peroxidation , endocrinology , ethanol , medicine , glutathione , antioxidant , alcohol , pharmacology , lipid profile , cholesterol , biochemistry , enzyme
Background: Chronic alcohol intake is related to hypertension. In the present work, we investigated the effect of Allablanckia floribunda Oliver (Clusiaceae) aqueous extract in alcohol-induced hypertensive rats and on related oxidative stress damages. Methods: Alcohol-induced hypertensive rats (AHR) was obtained by oral administration of ethanol (3 g/kg/day during 8 weeks). Blood pressure and heart rate were evaluated using the direct cannulation method. The effects of the extract on lipid profile as well as kidney and liver functions were studied. Free radical scavenging and antioxidant properties of the extract were evaluated by colorimetric method. The effects of A. floribunda were evaluated after 4 weeks of treatment with alcohol. Results: At the doses of 200 and 400 mg/kg/day, A. floribunda significantly decreased the mean blood pressure of AHR by 14.06 and 23.25 % respectively. Administration of the plant extract lead to the reduction of total cholesterol by 41.50% and 43.06%, HDL-cholesterol by 22.16 and 30.15% and artherogenic index by 69.78 and 74.43%, respectively at the doses of 200 and 400 mg/kg, as compared to untreated hypertensive rats. A. floribunda (200 and 400 mg/kg) decrease bilirubine (12.98 and 16.88%), urea (23.32% and 32.26 %), ALT (10.73 and 27.97%) and AST (29.80 and 42.22%) of treated AHR, respectively. The plant extract also reduced superoxide dismutase (SOD), malondialdehyde (MDA) and catalase and increased the reduced glutathione (GSH) concentration in aorta, heart, kidney and liver of AHR. Conclusion: These results suggest that the aqueous extract of A. floribunda possesses antioxidant and hypotensive activity in alcohol-induced hypertension