Decoction of Andrographis paniculata whole plant and Gymnema sylvestre leaves demonstrated noteworthy hypoglycemic activity in Sprague Dawley rat

Mother Nature is an elite source for the exploration of leads with good hypoglycemic potential. Progressing in the direction of research, two well-known plants from the Indian subcontinent; A. paniculata (Family: Acanthaceae) and G. sylvestre (Family: Apocynaceae) were chosen and evaluated for their hypoglycemic property in alloxan induced diabetic rat model using metformin hydrochloride as the standard drug. In the current investigation, whole plant decoction of A. paniculata and decoction of G. sylvestre leaves were utilized. The research specified preliminary phytochemical investigations which facilitated better understanding the role(s) of natural bioactive molecules in mediating the activity and their probable mechanism(s). The results represented that the combined decoction of plants significantly exerted the hypoglycemic effect. The glucose lowering activity was mediated by active polyphenol or flavonoid principles present in the decoction which may be believed to enhance the transportation of blood glucose level in the peripheral tissues or via potentiation of insulin secretion from the pancreatic β-cells. The present study reflects the perception to be used clinically according to the toxicity profiles. The research may hold perspective for the development of formulations based on above two natural principles and may open innovative avenues for managing hyperglycemia