Open AccessAntiviral activities of Cucumis metuliferus fruits alkaloids on Infectious Bursal Disease Virus (IBDV)
Author(s) -
A.A. Anyanwu,
Nanloh S Jimam,
Simeon Omale,
Noel N. Wannang
Publication year - 2017
Publication title -
the journal of phytopharmacology
Language(s) - English
Resource type - Journals
ISSN - 2320-480X
DOI - 10.31254/phyto.2017.6206
Subject(s) - infectious bursal disease , virus , virology , fibroblast , biology , alkaloid , cucumis , cell culture , horticulture , botany , biochemistry , virulence , genetics , gene
Objective: The toxicity of the alkaloids isolated from the fruit pulp of Cucumis metuliferus was investigated in chicken fibroblast cells. Materials and Methods: The alkaloids from C. metuliferus fruit pulp were isolated and their effects assayed on infectious bursal disease virus (IBDV) using chicken ebryo fibroblast cells. Results: There was no observed structural change on the chicken fibroblast cells when exposed to concentrations of 0.195 and 100 mg/ml of the alkaloids; and there was observed antiviral activities on IBDV at concentration between 6.125 and 100 mg/ml, while concentrations of the alkaloids between 0.195 to 3.125 mg/ml showed no antiviral activities compared to the control. Conclusion: The alkaloid showed good margin of safety on chicken fibroblast cells, with antiviral activities on infectious bursal disease virus (IBDV).