Open AccessEvaluation of Anti-arthritic activity of Ficus benghalensis Linn. root extracts on Freund’s adjuvant induced Arthritis in rats
Author(s) -
Lokesh K. Bhardwaj,
Kaushal K. Chandrul,
Ushma Sharma
Publication year - 2016
Publication title -
the journal of phytopharmacology
Language(s) - English
Resource type - Journals
ISSN - 2320-480X
DOI - 10.31254/phyto.2016.5103
Subject(s) - edema , arthritis , traditional medicine , pharmacology , ethanol , body weight , medicine , chemistry , hemoglobin , erythrocyte sedimentation rate , adjuvant , biochemistry
The present study was carried out to evaluate the anti-arthritic activity of ethanol and aqueous extract of root of Ficus benghalensis on Freund’s adjuvant induced arthritis in rats. The crude ethanol and aqueous root extract was administered orally at dose of 300mg/kg body weight for 28 days. Indomethacin at dose of 10mg/kg body weight was used as standard drug. The paw volume was measured on days 7, 14, 21 and 28. At the end of day 28th the animals were anaesthetized with anesthetic ether and blood was collected from retro-orbital route to all the groups of animals and various haematological parameters such as hemoglobin content, total WBC, RBC and erythrocyte sedimentation rate (ESR) were estimated. The body weight of the animals was measured by digital balance to access the course of the disease at the initial day before induction and the end of 28th day. The results indicate that at the dose of 300mg/kg b.w, both the extracts protect the rats against primary and secondary arthritic lesions, body weight changes and haematological perturbations induced by FCA. Daily treatment with crude extracts and standard drug effectively inhibits paw edema in rats. Both the extracts significantly (p<0.01) altered the parameters which were estimated, when compared to control group rats. The observations showed that ethanol extract show highly inhibition of paw edema in rats. The ethanol extract inhibits rat paw edema by 63.64% than the aqueous extract 31.82% when compared to standard drug 62.34% on 28th day. At the end of study the ethanol extract show more pronounce effect then aqueous extract when compared to standard drug. Our findings showed a significant anti-arthritic activity of Ficus benghalensis root extracts against FCA induced arthritis in rats.