Open AccessImpact of Solanum surettense on membrane bound Na+/K+ ATPase and in vivo anti oxidants activity on isoproterenol induced myocardial injury in rats
Author(s) -
Chitikela P Pullaiah,
S Dhanunjaya,
GV. Narasimha Kumars,
D. Pichaiah,
M. Venkateswarlu,
D Ranganayakulu
Publication year - 2015
Publication title -
the journal of phytopharmacology
Language(s) - English
Resource type - Journals
ISSN - 2320-480X
DOI - 10.31254/phyto.2015.4302
Subject(s) - catalase , pharmacology , glutathione , in vivo , chemistry , propranolol , isoprenaline , lactate dehydrogenase , antioxidant , cardioprotection , enzyme , atpase , myocardial infarction , medicine , biochemistry , biology , microbiology and biotechnology , stimulation
The present study was designed to evaluate the cardio protective potential of ethanolic extract of Solanum surettense a warm-climate annual herb, on isoproterenol-induced Myocardial Infarction (MI) in rats. Five groups of albino rats, each comprising six animals, were selected for this study. Group I served as a control, Group II rats were given isoproterenol (ISO) (85mg/kg subcutaneously), and Group III rats were treated with propranolol 10mg/kg as standard treatment. Groups IV and V rats were given ESS (200 mg/kg and 400 mg/kg, respectively) along with isoproterenol (85mg/kg). At end of the study cardiac biomarkers like CK-MB and LDH were estimated to accesses cardio protection. The protective effect of heart is also accessed by estimation of membrane bound Na+ /K+ATPase and tissue antioxidant enzymes like SOD, Catalase and GSH. ESS pre treated animals in various doses significantly decreased the levels of CK-MB and LDH when compared with ISO treated animal. The dose of 400 mg/kg has shown significant protection than 200 mg/kg of ESS i.e. dose dependent cardio protection. The study confirms the cardio protective potential of ethanolic extract of Solanum surettense against isoproterenol-induced biochemical alterations in rats.