Open AccessIn-vitro thrombolytic and cytotoxic activity of methanolic extract of Syzygium operculatum leaves
Author(s) -
Ibrahim Tarek,
Abul Hasanat,
Mohammad Shah Hafez Kabir,
Tanvir Ahmad Chowdhury,
Md. Moshiur Rahman,
Mir Ezharul Hossain
Publication year - 2015
Publication title -
the journal of phytopharmacology
Language(s) - English
Resource type - Journals
ISSN - 2320-480X
DOI - 10.31254/phyto.2015.4205
Subject(s) - brine shrimp , bioassay , streptokinase , cytotoxicity , cytotoxic t cell , traditional medicine , pharmacology , syzygium , thrombolytic drug , chemistry , medicine , in vitro , biology , biochemistry , genetics , myocardial infarction , thrombolysis
The existing study was made to investigate the thrombolytic exercise and cytotoxic potential with the methanol extract of Syzygium operculatum leaves. The cytotoxicity had been assessed while using brine shrimp lethality bioassay and also thrombolytic impact with individual blood. The brine shrimp lethality bioassay was employed to evaluate cytotoxicity (LC50=272.82μg/ml) compared to vincristine associated with sulphate (LC50=0.512μg/ml). It had been also assessed as thrombolytic agent compared to streptokinase. It's got Significant thrombolytic exercise (36. 28%) compared to standard streptokinase (75.09%).