Open AccessEffect of aqueous extract of Talinum triangulae (water leave) in lead- induced chromosomal aberration
Author(s) -
Olakunle Bamikole Afolabi,
O.I Oloyede,
Tugbobo Oladimeji
Publication year - 2014
Publication title -
the journal of phytopharmacology
Language(s) - English
Resource type - Journals
ISSN - 2320-480X
DOI - 10.31254/phyto.2014.3403
Subject(s) - micronucleus test , genotoxicity , bone marrow , micronucleus , lead acetate , positive control , toxicology , andrology , negative control , physiology , biology , chemistry , pharmacology , medicine , toxicity , traditional medicine , immunology
Phytomedicine is a subject that is now gaining relevance worldwide aiding treatment for diseases that were once incurable among folks in which genotoxicity is a prominent one. The present study was designed to examine the ability of Talinum triangulare (water leaf) to protect the genomic integrity of swiss albino rat from lead-induced chromosomal damage in the bone marrow red blood cells. 20 eight week old rats were divided into five groups with group 1 as the negative control and group 2 is the positive control and the other groups, all treated by gavage once per day with a single dose of 2.5 mg/ml lead acetate. The frequency of micronuclei formed was examined in the bone marrow erythroblast of the treated and untreated groups through standard micronuclei assay method. The plant shows significant (p<0.05) difference in genoprotective ability in the group treated with 200 mg/kg body weight of the aqueous extract of the plant over 100 and 400 mg/kg b.w when the level of the micronucleated proerythroblast formed in the bone marrow was considered and a substantial decrease in the number of polychromatophilic erythroblasts (PCEs) scored from the stained blood cells in the groups respectively. It is shown in the present study that lead-induced chromosomal damage could be averted measurably by dietary consumption of Talinum triangulare.