Open AccessAntiinflammatory and antioxidant activity of extracts and isolated compounds from Derris brevipes Benth (Baker)
Author(s) -
Rajesh S. Telekone,
Mohammad Shoaib Khan
Publication year - 2014
Publication title -
the journal of phytopharmacology
Language(s) - English
Resource type - Journals
ISSN - 2320-480X
DOI - 10.31254/phyto.2014.3305
Subject(s) - antioxidant , chemistry , flavonoid , chloroform , chalcone , traditional medicine , methanol , singlet oxygen , organic chemistry , medicine , oxygen
The role of medicinal plants in promoting the ability of human health to cope with the unpleasant and difficult situations is well documented from ancient times till date all over the world. The purpose of this study is to define antioxidant and anti-inflammatory activity of chloroform, methanol extract and isolated flavonoid compounds 2’,4’-dihydroxy-4-methoxy-3’- prenyl chalcone (compound 1) and Leutolin (compound 2) from the methanol extract of Derris brevipes Benth (Baker). This study displayed potential total antioxidant capacity, reducing power, efficacy in scavenging singlet oxygen and nitric oxide radicals of extracts and isolated compounds. The study also revealed anti-inflammatory capability of extracts and compounds. Out of the two extracts, methanol extract showed higher antiinflammatory activity and of the two compounds compound 2 outscored compound 1 in antiinflammatory efficacy. As an antiinflammatory test molecule the efficacy of compound 2 was nearly equal to that of the standard ibuprofen. IC50 values for antioxidant activities were also less for methanol extract and compound 2 as compared to chloroform extract and compound 1. These results confirm the role of isolated flavonoids as promising free radical scavengers, potent antioxidants and antiinflammatory agents.