Open AccessImmunomostimulant phytoconstituents from Mangifera indica L. bark oil
Author(s) -
Chetan Savant,
Anand Rao Kulkarni,
Basheerahmed Abdulaziz
Publication year - 2014
Publication title -
the journal of phytopharmacology
Language(s) - English
Resource type - Journals
ISSN - 2320-480X
DOI - 10.31254/phyto.2014.3210
Subject(s) - mangifera , immunostimulant , traditional medicine , bark (sound) , medicine , levamisole , negative control , azadirachta , pharmacology , biology , immunology , botany , immune system , ecology
The present study was undertaken to isolate oil from Mangifera indica bark, Identification of various phytoconstituents and screening of immunostimulant activity in experimental animals. Methods: Immunostimulant activity was evaluated in rats as well as in mice by determining neutrophil adhesion to nylon threads and phagocytic index. Levamisole at a dose of 50 mg/kg, b.w was used as standard drug. Acute toxicity studies were carried out and the test drug doses were selected. Mangifera indica bark oil in the dose of 150 & 300 mg/kg b.w, p.o, were used. Results: Results indicate a significant increase in percent neutrophil adhesion (P<0.01) for test and standard groups compared to control group and haemagglutination antibody (HA) titer (P<0.01) and phagocytic index (P<0.001) values are also significantly increased in test groups. Conclusion: The results obtained in the present study indicate that Mangifera indica Linn bark oil possesses potent immunomodulatory activity and have therapeutic efficacy for the prevention of autoimmune and infectious diseases.